Tetrabutylammonium fluoride trihydrate

Tetrabutylammonium fluoride trihydrate (TBAF.3H2O) is commonly used in pharmaceutical manufacturing as a source of nucleophilic fluoride for the preparation of various organic compounds. It is a useful phase-transfer catalyst and a reagent in the production of pharmaceuticals where it is utilized for desilylation or fluorination of organic compounds. It is also employed in the preparation of β-fluoroamines and heterocycles by cyclisation reactions.