Excipients for pharmaceutical and supplement capsules
Superior quality
With two production facilities in Germany, IOI Oleo is the leading supplier of medium-chain triglycerides (MCT) and associated products in Europe. Whether developing medicinal capsules or dietary supplements, the company prioritizes the health and well-being of consumers. This commitment drives IOI Oleo’s efforts to ensure the highest quality in everything it produces.
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Capsules are one of the most popular dosage forms
After tablets, capsules are the second most popular dosage form among consumers. Experts predict, however, that the market for capsules will continue to see double-digit growth rates over the next decade.
Their popularity is no surprise, given their numerous advantages. Consumers appreciate how easy capsules are to take, for example, and that they help avoid the often unpleasant taste of active ingredients or excipients.
Capsules are a game-changer for developers, too, and during production. They are easy to dose, precise, cheap to make, and long-lasting – and they save space. They also allow for sensitive ingredients to be processed gently.
There are three different types of capsules: hard, soft, and chewable.
Focusing on essential ingredients
As more and more products are being developed with simple formulas, capsule manufacturers are focusing on the ingredients that are needed to deliver active ingredients most effectively. IOI Oleo’s portfolio includes a range of new, functional lipids that can be used in all types of capsules while delivering:
- a wide range of properties and textures
- nutritional benefits linked to the unique metabolic processes associated with medium-chain lipids
- plant-based origins
- effective mitigation of the poor solubility of active ingredients in BCS classes II and IV, allowing them to be successfully administered through special drug delivery systems like SEDDS
PRODUCT | COMPENDIAL TITLE/ CHEMICAL DESCRIPTION | PRIMARY SCOPE OF USE | MELTING POINT | CONSISTENCY AT ROOM TEMPERATURE | MONOESTER CONTENT (%) | HYDROXYL VALUE (MG KOH/G) | FUNCTION |
---|---|---|---|---|---|---|---|
SOFTISAN® 378 | Hard Fat | Pharma | ~ 39 | soft-creamy paste | < 1 | < 50 | Carrier |
IMWITOR® 308 | Glycerol monocaprylate, type II | Pharma | 27-33 | solid | > 80 | 450 - 550 | Carrier, Solubilizer & Bio-availibility booster |
IMWITOR® 742 | Glycerol monocaprylocaprate, type I (available with CEP support) | Pharma | ~ 25 | pasty to solid | 45 - 75 | 315 - 380 | Carrier, Solubilizer & Bio-availibility booster |
IMWITOR® 988 | Glycerol monocaprylate, type I | Pharma | ~ 23 | liquid | 45 - 75 | 315 - 380 | Carrier, Solubilizer & Bio-availibility booster |
MIGLYOL® 812 N | Triglycerides, medium-chain | Pharma | < 0 | liquid | < 1 | <10 | Carrier, Lubricant |
MIGLYOL® 810 N | Triglycerides, medium-chain | Pharma | < 0 | liquid | < 1 | <10 | Carrier, Lubricant |
WITARIX® MCT 60/40 | Caprylic/Capric triglyceride | Nutraceutical | < 0 | liquid | < 0 | <10 | Carrier, Glazing and release agent, Lubricant |
WITARIX® MCT 70/30 | Caprylic/Capric triglyceride | Nutraceutical | < 0 | liquid | < 0 | <10 | Carrier, Glazing and release agent, Lubricant |
WITARIX® MCT C8 | Caprylic triglyceride | Nutraceutical | < 0 | liquid | < 0 | <10 | Carrier, Glazing and release agent, Lubricant |
WITARIX® MCT powder AC8CN | Caprylic triglyceride and gum acacia | Nutraceutical | < 0 | powder | < 0 | <10 | Solution for an easy-to-handle powder, with a high oil load and good solubility |
The capsule ingredients from IOI Oleo demonstrate both market-leading stability (Rancimat test and conductivity measurement) and polarity (suitability for formulation).
Bioavailability
IOI Oleo’s medium-chain partial glycerides (MCPGs) and triglycerides (MCTs) are characterized by a number of key properties that make them important as carriers and bioavailability-enhancers in nutraceutical and pharmaceutical applications. These include solubility, excellent permeability and transport, particle dispersion, rapid absorption, versatility, compatibility, taste and odor neutrality, safety and metabolization.
Active substances
Active ingredients such as hormones, cannabinoids, protease inhibitors, alpha-blockers, androgen blockers, tyrosine kinase inhibitors, vitamins and vitamin derivatives can all be supplied in capsules using IOI Oleo excipients.
Sustainability
IOI Oleo has established a vision to lead the way in both the production and procurement of sustainable palm oil.
The company is committed to cultivating sustainable oil palm plantations and implementing a responsible global palm oil supply chain.
This includes the basic availability of all palm oil-based specialties in RSPO M/B quality.
For more information, please contact:
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Distributed in:
Austria, Bosnia-Herzegovina, Croatia, the Czech Republic, Germany, Hungary, the Nordic countries, Poland, Slovakia and Slovenia.
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Excipients for pharmaceutical and supplement capsules
![Botanical extracts from new partner Ransom Naturals Ltd. white flower with leaves](https://www.nordmann.global/_Resources/Persistent/6/e/a/f/6eaf9c2b827bb66c25c9150640bf477b704f7773/ransom%20naturals-2251x1689.jpeg)
Botanical extracts from new partner Ransom Naturals Ltd.
![Delicious and nutritious – for every meal! Delicious and nutritious – for every meal!](https://www.nordmann.global/_Resources/Persistent/8/a/6/7/8a67a8db7ef8cbfde491fb09d758d5ae631cc182/Rabeler_Mango-1628x1221.jpg)